Salicylates Interfere with Oxidative Phosphorylation Enzymes

Created on Mon, 06/15/2015 - 16:47
Last updated on Mon, 06/15/2015 - 16:47

Salicylates cause lactic acidosis by interfering with the enzymes of Krebs cycle.

Specifically, alpha-ketoglutarate dehydrogenase and succinic acid dehydrogenase appear to be targets.

lactic acidosis due to salicylate toxicity

Obviously this sort of uncoupling would lead to increased anaerobic metabolism, and therefore lactate levels would rise.

However, it seems clinically that the lactate levels in these people rise only infrequently, which makes salicylates an unusual cause of lactic acidosis. The lactate may be slightly elevated, but does little to contribute to the overall acidosis picture.

 

References

Kaplan, E. H., Jean Kennedy, and Jane Davis. "Effects of salicylate and other benzoates on oxidative enzymes of the tricarboxylic acid cycle in rat tissue homogenates." Archives of biochemistry and biophysics 51.1 (1954): 47-61.

Bartels, P. D., and H. Lund-Jacobsen. "Blood lactate and ketone body concentrations in salicylate intoxication." Human & Experimental Toxicology5.6 (1986): 363-366.