Interpreting the Shape of the Flow-volume Loop

Created on Sat, 09/26/2015 - 18:50
Last updated on Sat, 09/26/2015 - 22:05

Typically, when one thinks of flow-volume loops, one refers to the classical loops of forced expiratory spirometry. Most of what is written about flow-volume loops refers to these. Indeed, both the LITFL entry on flow-volume loops and the AnaesthesiaUK revision article use the formal pulmonary function test standard of flow-volume loop interpretation.

As you can see, the shape of the curves is quite similar, but the fundamental difference is in the fact that in the ventilator loop is by convention upside-down.

comparison of ventilator and spirometer flow-volume loops

The turbine gives rise to a controllable and adjustable inspiratory flow (you can have whatever flow pattern you want!). The inspiratory flow part of the loop is therefore more reflective of lung compliance: as the lung distends, the flow decreases.  Then, the patient exhales passively; here  airway resistance will be revealed as the determinant of  expiratory flow rate. 

With the classical spirometer, the patient forcibly exhales into the machine; the peak expiratory flow rate and the shape of the expiratory flow-volume curve is therefore the best measure of airway resistance.

Normal flow-volume loops

Flow-volume loop in normal lung

Flow-volume loops in obstructive lung disease

Flow-volume loop in obstructive lung disease

Characteristic features of obstructive lung disease in the flow-volume loop include the following:

  • Low peak inspiratory flow
  • Low peak expiratory flow
  • Failure of the expiratory flow curve to reach zero (an "open loop")
  • A "scooped out" expiratory flow pattern

Flow-volume loops in restrictive lung disease

If the restrictive disease did nothing but reduce the volume of the lung, the curve would look rather normal, but diminished in size, as depicted below.

Flow-volume loop in obstructive lung disease

However, usually the lung disease also causes a decrease in lung compliance.

The curve assumes a different shape:

Characteristic features of restrictive lung disease in the flow-volume loop include the following:

  • Low tidal volume
  • Rapid decrease in inspiratory flow
  • Rapid expiratory flow, with a high peak expiratory flow rate (as the inelastic lung recoils)

The effects of a circuit leak on flow-volume loops

Flow-volume loop with a cuff leak



Most of this information comes from only two textbooks. With "Basic Assessment and Support in Intensive Care" by Gomersall et al (as well as whatever I picked up during the BASIC course) as a foundation, I built using the humongous and canonical "Principles and Practice of Mechanical Ventilation" by Tobins et al – the 1442 page 2nd edition.

Frank Rittner, Martin Doring. Curves and loops in mechanical ventilation. not sure what year; published by Drager.

R Scott Harris, Pressure-Volume Curves of the Respiratory System Respir Care 2005;50(1):78–98. © 2005

Sterner, James B., et al. "Inspiratory flow-volume curve evaluation for detecting upper airway disease." Respiratory care 54.4 (2009): 461-466.